منابع مشابه
The Mechanism of Action of Antilturnour Platinum Compounds
As a result of observations madc by Roscnberg in the early 1960s~ a range of platinum compounds have been discovered which have significant anti-tumour properties (I, 2). The two prototype compounds originally mvcstigated are the cis isomers of diamminoplatinum(I1) dichloride and diammino-platinum(1V) tetrachloride. The stercochemistries are shown in Figure I . The t ~ m s i omers of these comp...
متن کاملInduction of DNA-protein cross-links by platinum compounds.
The differences between cis- and trans-diamminedichloroplatinum II (DDP) in forming DNA-protein cross-links in isolated human lymphocytes were investigated. Both cis- and trans-DDP can induce DNA-protein cross-links. We show that cis-DDP forms complexes between DNA and proteins faster than trans-DDP. This results from an increase in the quantity of DNA and platinum together with an increase in ...
متن کاملStructure, activity and mode of action of antitumor platinum compounds
Chantitative relationship beween activity and structure of antitumor platinum complexes was studied by C W / 2 method. On the basis of the obtained regression results, some new platinum complexes with methyl substituted aliphatic and cycloaliphatic mines were synthesized and screened, and a new complex [Pt(~PDA)(Cl-Ac),l possessing high activity as cisplatin but with much laver toxicity was fou...
متن کاملDeveloping Central Nervous System and Vulnerability to Platinum Compounds
Comparative studies on the effects of the platinum complexes in use or in clinical trials are carried out in order to discover differences in the neurotoxic potential and the reversibility of neurotoxicity. In this paper, we summarized the current literature on neurotoxicity and chemoresistance of cisplatin (cisPt) and discussed our recent efforts on the interference of cisPt and a new platinum...
متن کاملPlatinum (II) Compounds With Antitumor Activity Studied by Molecular Mechanics
A SERIES OF PT(LL) COMPLEXES WITH ANTITUMOR PROPERTIES: [1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]PtL(2) (meso-1-PtL(2)) and [erythro-1-(2,6-dichloro-4-hydroxyphenyl)-2-(2-halo-4-hydroxyphenyl)ethylenediamine]PtL(2), [2L=2Cl-,2I-,SO(4) (2)-; halo = F (erythro-8-PtL(2)),halo = Cl (erythro-9-PtL(2))] has been modelled by molecular mechanics (MM). The MM calculations were carried out f...
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ژورنال
عنوان ژورنال: J. Chem. Soc., Trans.
سال: 1891
ISSN: 0368-1645
DOI: 10.1039/ct8915900598